Mood and cognitive effects of transcranial direct current stimulation in post-stroke depression

被引：79

作者：

Bueno, Viviane F. ^{[1
,2
]}

Brunoni, Andre R. ^{[1
,2
]}

Boggio, Paulo S. ^{[3
,4
]}

Bensenor, Isabela M. ^{[1
]}

Fregni, Felipe ^{[2
,5
]}

机构：

[1] Univ Sao Paulo, Ctr Pesquisas Clin, Univ Hosp, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Psicol, Nucl Neurociencias & Comportamento, BR-05508 Sao Paulo, Brazil

[3] Univ Prebiteriana Mackenzie, Cognit Neurosci Lab, Ctr Hlth & Biol Sci, Sao Paulo, Brazil

[4] Univ Prebiteriana Mackenzie, Dev Disorders Program, Ctr Hlth & Biol Sci, Sao Paulo, Brazil

[5] Harvard Univ, Sch Med, Lab Neuromodulat, Spaulding Rehabil Hosp, Boston, MA 02114 USA

来源：

NEUROCASE | 2011年 / 17卷 / 04期

关键词：

Post-stroke depression; Major depressive disorder; Case report; Electric stimulation therapy; Stroke; UNAFFECTED HEMISPHERE; MAGNETIC STIMULATION; FUNCTION IMPROVEMENT; PARKINSONS-DISEASE; BRAIN POLARIZATION; MAJOR DEPRESSION; STROKE PATIENTS; MECHANISMS; CORTEX; MEMORY;

D O I：

10.1080/13554794.2010.509319

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Depression following stroke (PSD) affects up to 33% of patients and is associated with increased mortality. Antidepressant drugs have several side effects; therefore novel treatments are needed. Transcranial direct current stimulation (tDCS) has induced mood and cognitive gain in several neuropsychiatric conditions but has not been tested for PSD to date. Here, we report a patient with significant mood and cognitive impairment who showed marked amelioration of these symptoms following anodal stimulation (2 mA per 30 minutes per 10 days) over the left dorsolateral prefrontal cortex. We discuss the possible mechanisms of tDCS in improving PSD. This initial preliminary data is useful to encourage further controlled trials on the field.

引用

页码：318 / 322

页数：5

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