Thymosin β4 increases hair growth by activation of hair follicle stem cells

被引：95

作者：

Philp, D ^{[1
]}

Nguyen, M ^{[1
]}

Scheremeta, B ^{[1
]}

St-Surin, S ^{[1
]}

Villa, AM ^{[1
]}

Orgel, A ^{[1
]}

Kleinman, HK ^{[1
]}

Elkin, M ^{[1
]}

机构：

[1] NICHHD, Cell Biol Sect, NIH, Bethesda, MD 20892 USA

来源：

FASEB JOURNAL | 2003年 / 17卷 / 15期

关键词：

matrix metalloproteinase-2; clonogenic keratinocytes;

D O I：

10.1096/fj.03-0244fje

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymosin beta(4), a 43-amino acid polypeptide that is an important mediator of cell migration and differentiation, also promotes angiogenesis and wound healing. Here, we report that thymosin beta(4) stimulates hair growth in normal rats and mice. A specific subset of hair follicular keratinocytes in mouse skin expresses thymosin beta(4) in a highly coordinated manner during the hair growth cycle. These keratinocytes originate in the hair follicle bulge region, a niche for skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely related, if not identical, to the bulge-residing stem cells, were isolated and their migration and differentiation increased in the presence of nanomolar concentrations of thymosin beta(4). Expression and secretion of the extracellular matrix-degrading enzyme matrix metalloproteinase-2 were increased by thymosin beta(4). Thus, thymosin beta(4) accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.

引用

页码：385 / +

页数：16

共 46 条

[1] Thymosin β15 expression in tumor cell lines with varying metastatic potential [J].