Cyclodextrins in transdermal and rectal delivery

被引:151
作者
Matsuda, H
Arima, H
机构
[1] Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan
[2] Nihon Shokuhin Kako Co, Fuji, Shizuoka 4178530, Japan
关键词
cyclodextrin; complexation; skin; rectum; drug delivery; stability constant; drug release; drug absorption; permeability; local irritation;
D O I
10.1016/S0169-409X(98)00056-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Transdermal and rectal routes of drugs are very important as a useful supplement of oral routes and the direct exposing method of drugs when the systemic and local effects are required. The widespread use of parent cyclodextrins (CDs) and chemically modified CD derivatives (CD derivatives) for in-vitro and in-vivo dermal and rectal drug delivery have been evaluated. In addition, the application of hydrophilic CD derivatives to cosmetics have been progressing. fn this article, the current status of parent CDs and CD derivatives in the transdermal and rectal delivery of conventional low molecular weight agents are reviewed. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:81 / 99
页数:19
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