Bovine Serum Albumin-Poly(methyl methacrylate) Nanoparticles: An Example of Frustrated Phase Separation

被引：32

作者：

Ge, Jun ^{[1
]}

Lei, Jiandu ^{[1
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

NANO LETTERS | 2011年 / 11卷 / 06期

基金：

美国国家科学基金会;

关键词：

Protein-polymer conjugate; nanoparticles; phase separation; POLYMER; STABILITY;

D O I：

10.1021/nl201303q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new protein-polymer conjugate made of denatured bovine serum albumin (BSA) covalently bonded to poly(methyl methacrylate) (PMMA) is synthesized by attaching PMMA to acryloylated BSA followed by nanoparticle precipitation. Depending on the BSA to PMMA ratio, these conjugates self-assemble into uniform spherical nanoparticles which show "island" growth on the surface of the nanoparticles. This growth is promoted or retarded by exposing the nanopartides to different solvents, causing the two components to undergo incipient phase separation. Incipient phase separation of the BSA-PMMA conjugate two-component system was observed in single nanoparticles, resulting in "island" growth on the surface of the nanoparticles. Incipient phase separation of the BSA-PMMA conjugate two-component system was observed in single nanoparticles, resulting in "island" growth on the surface of the nanoparticles.

引用

页码：2551 / 2554

页数：4

共 16 条

[1] Nanoparticle polymer composites: Where two small worlds meet [J].