Dendritic cells in tumor immunology and immunotherapy

被引:31
作者
Turtle, CJ [1 ]
Hart, DNJ [1 ]
机构
[1] Mater Med Res Inst, Dendrit Cell Lab, Brisbane, Qld 4101, Australia
关键词
dendritic cells; cancer immunotherapy; vaccination; T lymphocytes;
D O I
10.2174/1389450043490640
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Despite rapid advances in cancer therapeutics, relapsed disease due to failed immunosurveillance remains a major problem in many cancers. Dendritic cells are recognized as key to the induction of immune responses to cancer and intensive study is underway to facilitate their use in cancer immunotherapy. In initial clinical trials, dendritic cell preparations were, with the benefit of hindsight, largely sub-optimal, yet encouraging results have been seen. The challenge now is to expand our knowledge of the interactions between tumors and the immune system, through basic scientific research and coordinated large-scale clinical studies. This review focuses on the anti-tumor immune response, human dendritic cell biology and the results of recent clinical studies of dendritic cell immunotherapy for cancer.
引用
收藏
页码:17 / 39
页数:23
相关论文
共 260 条
[1]   A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells [J].
Adema, GJ ;
Hartgers, F ;
Verstraten, R ;
deVries, E ;
Marland, G ;
Menon, S ;
Foster, J ;
Xu, YM ;
Nooyen, P ;
McClanahan, T ;
Bacon, KB ;
Figdor, CG .
NATURE, 1997, 387 (6634) :713-717
[2]   A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].
Akashi, K ;
Traver, D ;
Miyamoto, T ;
Weissman, IL .
NATURE, 2000, 404 (6774) :193-197
[3]   Targeting apoptotic tumor cells to FcγR provides efficient and versatile vaccination against tumors by dendritic cells [J].
Akiyama, K ;
Ebihara, S ;
Yada, A ;
Matsumura, K ;
Aiba, S ;
Nukiwa, T ;
Takai, T .
JOURNAL OF IMMUNOLOGY, 2003, 170 (04) :1641-1648
[4]   Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells [J].
Albert, ML ;
Jegathesan, M ;
Darnell, RB .
NATURE IMMUNOLOGY, 2001, 2 (11) :1010-1017
[5]  
AMBE K, 1989, CANCER, V63, P496, DOI 10.1002/1097-0142(19890201)63:3<496::AID-CNCR2820630318>3.0.CO
[6]  
2-K
[7]  
ANANDAHL EM, 2003, J IMMUNOL, V170, P2349
[8]   Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells [J].
Anderson, KL ;
Perkin, H ;
Surh, CD ;
Venturini, S ;
Maki, RA ;
Torbett, BE .
JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1855-1861
[9]   Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: A new approach for vaccine design [J].
Apostolopoulos, V ;
Yu, MM ;
Corper, AL ;
Teyton, L ;
Pietersz, GA ;
McKenzie, IFC ;
Wilson, IA .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 318 (05) :1293-1305
[10]   Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: A novel use of alternative anchors [J].
Apostolopoulos, V ;
Yu, MM ;
Corper, AL ;
Li, WJ ;
McKenzie, IFC ;
Teyton, L ;
Wilson, IA .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 318 (05) :1307-1316