Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the Children's Oncology Group

被引：112

作者：

Fujii, Hisaki ^{[1
]}

Cuvelier, Geoff ^{[1
]}

She, Kevin ^{[1
]}

Aslanian, Soudabeh ^{[1
]}

Shimizu, Hiromi ^{[1
]}

Kariminia, Amina ^{[1
]}

Krailo, Mark ^{[2
]}

Chen, Zhengjia ^{[3
]}

McMaster, Rob ^{[4
]}

Bergman, Axel ^{[4
]}

Goldman, Frederick ^{[5
]}

Grupp, Stephen A. ^{[6
]}

Wall, Donna A. ^{[7
]}

Gilman, Andrew L. ^{[8
]}

Schultz, Kirk R. ^{[1
]}

机构：

[1] Univ British Columbia, Div Hematol Oncol Bone Marrow Transplantat, British Columbia Childrens Hosp, Dept Pediat,Childrens Oncol Grp, Vancouver, BC V6H 3V4, Canada

[2] Univ So Calif, Childrens Oncol Grp, Dept Prevent Med, Los Angeles, CA USA

[3] Childrens Oncol Grp Operat Ctr, Arcadia, CA USA

[4] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[5] Univ Iowa, Iowa City, IA USA

[6] Childrens Hosp Philadelphia, Div Pediat Oncol, Philadelphia, PA 19104 USA

[7] Texas Transplant Inst, Methodist Childrens Hosp S Texas, San Antonio, TX USA

[8] Univ N Carolina, Chapel Hill, NC USA

来源：

BLOOD | 2008年 / 111卷 / 06期

关键词：

D O I：

10.1182/blood-2007-08-106286

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Numerous chronic graft-versus-host disease (cGVHD) biomarkers have been identified in limited, single-institution studies without validation. We hypothesized that plasma-derived biomarkers could diagnose, classify, and evaluate response in children with cGVHD. We performed a concomitant analysis of a number of known and predicted peripheral blood cGVHD biomarkers from a Children's Oncology Group (COG) phase 3 cGVHD therapeutic trial. A total of 52 newly diagnosed patients with extensive cGVHD were compared for time of onset after blood and marrow transplantation (BMT) (early, 3-8 months; late, ! 9 months) with 28 time-matched controls with no cGVHD (early, 6 months after BMT, late, 12 months after BMT). Soluble B-cell activation factor (sBAFF), anti-dsDNA antibody, soluble IL-2 receptor alpha (sIL-2R alpha), and soluble CD13 (sCD13) were elevated in patients with early-onset cGVHD compared with controls. sBAFF and anti-dsDNA were elevated in patients with late-onset cGVHD. Some of the biomarkers correlated with specific organ involvement and with therapeutic response. These 4 biomarkers had high specificity with higher sensitivity in combination. Changes in biomarker concentrations with immune reconstitution after transplantation significantly affected interpretation of results. The identified biomarkers have the potential for improved classification, early response evaluation, and direction of cGVHD treatment, but require validation in larger studies. This study is registered at www.cancer.gov/clinicaltrials as no. COG-ASCT0031.

引用

页码：3276 / 3285

页数：10

共 52 条

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