The role of the natural polyamine putrescine in defense against oxidative stress in Escherichia coli

被引：87

作者：

Tkachenko, A ^{[1
]}

Nesterova, L ^{[1
]}

Pshenichnov, M ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Perm 614081, Russia

来源：

ARCHIVES OF MICROBIOLOGY | 2001年 / 176卷 / 1-2期

基金：

俄罗斯基础研究基金会;

关键词：

polyamines; putrescine; oxidative stress; oxyyR; katG; expression level; cell survival;

D O I：

10.1007/s002030100301

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Putrescine up-regulated, in a concentration-dependent manner, the expression levels of the oxyR and katG genes of Escherichia coli cells exposed to hydrogen peroxide. Its stimulatory effect was more pronounced under conditions of strong oxidative stress. 1,4-Diamino-2-butanone, a specific inhibitor of putrescine synthesis, also inhibited oxyR expression under oxidative stress. When added to inhibited cells, putrescine relieved this inhibitory effect. Addition of putrescine to E. coli cultures exposed to oxidative stress led to increased cell survival.

引用

页码：155 / 157

页数：3

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