Mild and simple preparation of ketophosphine-boranes through uncatalysed hydrophosphination of enones

被引：17

作者：

Join, B ^{[1
]}

Delacroix, O ^{[1
]}

Gaumont, AC ^{[1
]}

机构：

[1] Univ Caen, Lab Chim Mol & Thioorgan, CNRS, UMR 6507,ENSIC, F-14050 Caen, France

来源：

SYNLETT | 2005年 / 12期

关键词：

enones; phosphorus; boron; gamma-ketophosphines; hydrophosphination;

D O I：

10.1055/s-2005-871576

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple method for the synthesis of gamma-ketophosphines is reported. This method is based on the atom efficient hydrophosphination reaction using secondary phosphine-boranes as precursors. Different examples with various substrates and phosphine precursors are described. The reaction occurs without any catalyst upon simple thermal activation (50-80 degrees C). Reduction of a gamma-ketophosphine yields in good yield and with an excellent diastereoselectivity a new hydroxyphosphine.

引用

页码：1881 / 1884

页数：4

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