Spongidepsin, a new cytotoxic macrolide from Spongia sp.

被引：47

作者：

Grassia, A

Bruno, I

Debitus, C

Marzocco, S

Pinto, A

Gomez-Paloma, L

Riccio, R

机构：

[1] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Salerno, Italy

[2] CNRS Pierre Fabre, IRD, F-31527 Ramonville St Agne, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 29期

关键词：

alkynes; cytotoxic; macrocyclic lactone; marine metabolites;

D O I：

10.1016/S0040-4020(01)00587-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel macrolide, spongidepsin (1) has been isolated from the Vanuatu marine sponge Spongia sp. The structure of 1, which contains 9-hydroxy-2,4,7-trimethyltetradeca-14-ynoic acid and N-methylphenylalanine residues joined in a 13-membered ring, was elucidated by spectroscopic analysis. Spongidepsin (1) showed cytotoxic activity against J774.A1, WEHI-164 and HEK-293 cancer cell lines with an IC50 in the sub-micromolar range. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6257 / 6260

页数：4

共 19 条

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[2] SCALAROLBUTENOLIDE, A NEW SESTERTERPENOID FROM THE MARINE SPONGE SPONGIA-NITENS [J].