A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

被引：36

作者：

Kiburu, Irene ^{[1
]}

Shurer, Andrew ^{[1
]}

Yan, Lei ^{[1
]}

Sintim, Herman O. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1039/b719423d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

引用

页码：518 / 520

页数：3

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