Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: A new system for anti-human immunodeficiency virus gene therapy

被引：22

作者：

Cannon, PM ^{[1
]}

Kim, N ^{[1
]}

Kingsman, SM ^{[1
]}

Kingsman, AJ ^{[1
]}

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,RETROVIRUS MOL BIOL GRP,OXFORD OX1 3QU,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 11期

关键词：

D O I：

10.1128/JVI.70.11.8234-8240.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type I U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.

引用

页码：8234 / 8240

页数：7

共 56 条

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