Fast multiresidue screening of 300 pesticides in water for human consumption by LC-MS/MS

被引:86
作者
Greulich, Kerstin [1 ]
Alder, Lutz [1 ]
机构
[1] Fed Inst Risk Assessment, D-14191 Berlin, Germany
关键词
liquid chromatography; tandem mass spectrometry; electrospray ionization; drinking water; pesticide; residue;
D O I
10.1007/s00216-008-1935-x
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The study tested the determination of 300 pesticides in mineral water at levels of 0.1 and 1.0 mu g/L. Measurements were conducted by direct sample injection into a liquid chromatograph coupled to a tandem mass spectrometer without any sample enrichment and/or cleanup. Two separate injections enabled the recording of two transitions per analyte (600 selected reaction monitoring transitions in total). For 285 analytes the sensitivity of direct sample injection (100 mu L) was sufficient to quantify residues at 0.1 mu g/L. All remaining pesticides were detected at 1.0 mu g/L. Calibration functions were linear for more than 80% of analytes. Signal suppression or enhancement compared with signals in high-performance liquid chromatography water was equal to or smaller than 20% for 240 analytes. Even the largest matrix-induced suppression did not result in the disappearance of peaks. Combining the results of seven mineral waters, the relative standard deviation of "recovery" was 20% or less for 87% of the substances. A second transition for confirmatory purposes was often available. Consequently, the proposed direct injection of samples without any sample enrichment and/or cleanup is suitable for screening of many pesticides in mineral and drinking water.
引用
收藏
页码:183 / 197
页数:15
相关论文
共 26 条
[1]   Residue analysis of 500 high priority pesticides: Better by GC-MS or LC-MS/MS? [J].
Alder, Lutz ;
Greulich, Kerstin ;
Kempe, Guenther ;
Vieth, Barbel .
MASS SPECTROMETRY REVIEWS, 2006, 25 (06) :838-865
[2]   Analysis of polar pesticides in rainwater in Denmark by liquid chromatography-tandem mass spectrometry [J].
Bossi, R ;
Vejrup, KV ;
Mogensen, BB ;
Asman, WAH .
JOURNAL OF CHROMATOGRAPHY A, 2002, 957 (01) :27-36
[3]   Preconcentration of contaminants in water analysis [J].
Bruzzoniti, MC ;
Sarzanini, C ;
Mentasti, E .
JOURNAL OF CHROMATOGRAPHY A, 2000, 902 (01) :289-309
[4]  
*BUND RIS, 2006, FAST MULT RES SCREEN
[5]  
*BUND RIS, 2006, COMPL ACQ PAR SETS P
[6]  
*EUR FOOD SAF AUTH, 2004, CONCL RISK ASS ACT S
[7]   Multi-residue method for the analysis of 101 pesticides and their degradates in food and water samples by liquid chromatography/time-of-flight mass spectrometry [J].
Ferrer, Imma ;
Thurman, E. Michael .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1175 (01) :24-37
[8]   Large scale pesticide multiresidue methods in food combining liquid chromatography-time-of-flight mass spectrometry and tandem mass Spectrometry [J].
Garcia-Reyes, Juan F. ;
Hernando, M. Dolores ;
Ferrer, Carmen ;
Molina-Diaz, Antonio ;
Fernandez-Alba, Amadeo R. .
ANALYTICAL CHEMISTRY, 2007, 79 (19) :7308-7323
[9]   Trace-level determination of pesticides in water by means of liquid and gas chromatography [J].
Geerdink, RB ;
Niessen, WMA ;
Brinkman, UAT .
JOURNAL OF CHROMATOGRAPHY A, 2002, 970 (1-2) :65-93
[10]   Comprehensive multi-residue method for the target analysis of pesticides in crops using liquid chromatography-tandem mass spectrometry [J].
Hiemstra, Maurice ;
de Kok, Andre .
JOURNAL OF CHROMATOGRAPHY A, 2007, 1154 (1-2) :3-25