Central obesity and hypertension - The role of plasma endothelin

被引:57
作者
Parrinello, G [1 ]
Scaglione, R [1 ]
Pinto, A [1 ]
Corrao, S [1 ]
Cecala, M [1 ]
DiSilvestre, G [1 ]
Amato, P [1 ]
Licata, A [1 ]
Licata, G [1 ]
机构
[1] UNIV PALERMO, DEPT INTERNAL MED, PALERMO, ITALY
关键词
obesity; central fat distribution; hypertension; endothelin;
D O I
10.1016/S0895-7061(96)00259-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Hypertension and central obesity are two conditions closely linked, but the mechanisms responsible for obesity-associated hypertension are still unclear. In the last few years, several studies addressed the role of endothelin-1 (ET-1) in the development and maintenance of hypertension. This study was designed to evaluate plasma ET-1 in normotensive and hypertensive central obese subjects compared with a lean healthy group. Our final goal was to analyze the relationship between plasma ET-1, blood pressure, and left ventricular structure and function in central obese subjects (both normotensives and hypertensives). ET-levels have been assessed by the radioimmunoassay method in 20 lean normotensives and in 57 central obese subjects; 30 of them were hypertensives and 27 of them were normotensives. Twenty-four-hour mean blood pressure (MBP/24 h) by noninvasive ambulatory blood pressure monitoring, left ventricular mass/ height (LVM/H), and left ventricular ejection fraction (LVEF) by echocardiography and peak filling rate (PFR) by radionuclide study were also measured. ET levels were significantly (P <.05) higher in obese hypertensives and obese normotensives than in lean normotensives. In addition, ET levels were significantly (P <.05) higher in obese hypertensives than in obese normotensives. ET were directly related to LVM/H (r = 0.86; P <.001) and MBP/24 h (r = 0.48; P <.009) but only in obese hypertensives. Multiple regression analysis indicated that ET-1 plasma levels remain an independent predictor of MBP/24 h and LVM/H also when age was included in the analysis. These data suggest that obesity-associated hypertension is characterized by an endothelial dysfunction that may contribute to the higher cardiovascular risk detectable in these patients. (C) 1996 American Journal of Hypertension, Ltd.
引用
收藏
页码:1186 / 1191
页数:6
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