A general amination method based on the addition of polyfunctional arylmagnesium reagents to functionalized arylazo tosylates

被引：86

作者：

Sapountzis, I ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 07期

关键词：

amination; Grignard reaction; halogen-magnesium exchange; heterocycle synthesis; synthetic methods;

D O I：

10.1002/anie.200353241

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot reaction sequence consisting of a Grignard reaction, allylation, and reduction provides new functionalized diarylamines in good yields (see scheme, Ts = toluene-4-sulfonyl, NMP = N-methylpyrrolidine, TFA = trifluoroacetic acid). In the first step azoaryl tosylates, which are readily obtained from aromatic amines, are treated with a myriad of functionalized organomagnesium compounds.

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页码：897 / 900

页数：4

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