Calcium signalling in lymphocytes

被引：102

作者：

Winslow, MM ^{[1
]}

Neilson, JR

Crabtree, GR

机构：

[1] Stanford Univ, Program Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Immunol & Microbiol, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(03)00050-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The modulation of intracellular calcium ion concentration, [Ca2+](i), is a common signalling mechanism used in many biological systems. B and T lymphocytes rely on Ca2+ signalling to initiate both developmental and activation programs. Recent data has shed new light on the initiation of this signalling pathway, the connection between the release of intracellular Ca2+ stores and the influx of extracellular Ca2+, and the molecular identity of the elusive Ca2+ release-activated Ca2+ (CRAC) channel. In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca2+](i) and the Ca2+-dependent phosphatase calcineurin.

引用

页码：299 / 307

页数：9

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