Diagnostic imaging using rare-earth chelates

被引：9

作者：

Hubbard, DS

Houlne, MP

Kiefer, G

Janssen, HF

Hacker, C

Bornhop, DJ ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

[2] Univ Med Ctr, SW Canc Ctr, Lubbock, TX USA

[3] Dow Chem Co, Designed Chem R&D, Freeport, TX USA

[4] Texas Tech Univ, Hlth Sci Ctr, Dept Orthoped, Lubbock, TX 79409 USA

来源：

LASERS IN MEDICAL SCIENCE | 1998年 / 13卷 / 01期

关键词：

fluorescence; lanthanide chelate; probes; tissue selectivity;

D O I：

10.1007/BF00592956

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new class of polyazamacrocyclic chelates of terbium is studied that have rich spectroscopic properties, tissue selectivity [1], millisecond fluorescence lifetimes, sharply spiked emission spectra (< 15 nm FWHM), large Stokes shifts (> 280 nm), good water solubility [1] and high fluorescence quantum yields (similar to 0.6 for PCTMB) [1]. We report our in vitro and ex vivo spectroscopic evaluation of these chelates. Additionally results from cellular binding specificity studies using Sprague-Dawley rats with UMR 108 osteosarcomas are presented. Finally, endoscopic imaging of dosed tissue demonstrates the potential to use the Tb(III) chelates as contrast enhancement markers.

引用

页码：14 / 21

页数：8

共 21 条

[1] MRI CONTRAST AGENTS - MACROCYCLIC LANTHANIDE(III) COMPLEXES WITH IMPROVED RELAXATION EFFICIENCY [J].