Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells

被引：32

作者：

Ahn, Quein ^{[1
]}

Jeong, Soo-Jin ^{[1
]}

Lee, Hyo-Jung ^{[1
]}

Kwon, Hee-Young ^{[1
]}

Han, Ihn ^{[1
]}

Kim, Hyun Seok ^{[2
]}

Lee, Hyo-Jeong ^{[1
]}

Lee, Eun-Ok ^{[1
]}

Ahn, Kwang Seok ^{[1
]}

Jung, Min-Hyung ^{[3
]}

Zhu, Shudong ^{[4
]}

Chen, Chang-Yan ^{[4
]}

Kim, Sung-Hoon ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea

[2] Yonsei Univ, Sch Med, Seoul 120752, South Korea

[3] Kyung Hee Univ, Sch Med, Seoul 130701, South Korea

[4] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

CANCER LETTERS | 2010年 / 298卷 / 02期

关键词：

Decursin; Apoptosis; COX; 2; Survivin; KBM; 5; ANGELICA-GIGAS; TARGETING SURVIVIN; PROSTATE-CANCER; THERAPY; EXPRESSION; COX-2; ERYTHROLEUKEMIA; RESISTANCE; CARCINOMA; CASCADE;

D O I：

10.1016/j.canlet.2010.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We demonstrate that decursin induces apoptosis via regulation of cyclooxygenase-2 (COX-2) and survivin in leukemic KBM-5 cells By activating an apoptotic machinery decursin is cytotoxic to KBM-5 cells In this apoptotic process decursin can activate caspase family members and triggers PARP cleavage At the same time the expression of COX-2 and survivin in the cells is downregulated Furthermore decursin is in synergy with COX-2 inhibitor celecoxib or NS398 for the induction of apoptosis Overall these results suggest that decursin via inhibiting COX-2 and survivin sensitizes human leukemia cells to apoptosis and is a potential chemotherapeutic agent to treat this disease (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：212 / 221

页数：10

共 34 条

[1] Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas [J].

Ahn, KS ;

Sim, WS ;

Kim, IH .

PLANTA MEDICA, 1996, 62 (01) :7-9

[2] COX-2 and cancer: a new approach to an old problem [J].

Bakhle, YS .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134 (06) :1137-1150

[3]

BEDI A, 1994, BLOOD, V83, P2038

[4]

Bobadilla Rodel V, 2005, Adv Nurse Pract, V13, P48

[5] The role of survivin for radiation therapy -: Prognostic and predictive factor and therapeutic target [J].

Capalbo, Gianni ;

Roedel, Claus ;

Stauber, Roland H. ;

Knauer, Shirley K. ;

Bache, Matthias ;

Kappler, Matthias ;

Roedel, Franz .

STRAHLENTHERAPIE UND ONKOLOGIE, 2007, 183 (11) :593-599

[6] Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells [J].

Carter, BZ ;

Mak, DH ;

Schober, WD ;

Cabreira-Hansen, M ;

Beran, M ;

McQueen, T ;

Chen, WJ ;

Andreeff, M .

BLOOD, 2006, 107 (04) :1555-1563

[7] COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma [J].

Erkanli, Serkan ;

Bolat, Filiz ;

Kayaselcuk, Fazilet ;

Demirhan, Beyhan ;

Kuscu, Esra .

GYNECOLOGIC ONCOLOGY, 2007, 104 (02) :320-325

[8] Chronic myelogenous leukemia: Biology and therapy [J].

Faderl, S ;

Talpaz, M ;

Estrov, Z ;

Kantarjian, HM .

ANNALS OF INTERNAL MEDICINE, 1999, 131 (03) :207-219

[9] Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer [J].

Falandry, C. ;

Canney, P. A. ;

Freyer, G. ;

Dirix, L. Y. .

ANNALS OF ONCOLOGY, 2009, 20 (04) :615-620

[10] The biochemistry of apoptosis [J].

Hengartner, MO .

NATURE, 2000, 407 (6805) :770-776

← 1 2 3 4 →