Relatedness of Human and Animal Clostridium difficile PCR Ribotype 078 Isolates Determined on the Basis of Multilocus Variable-Number Tandem-Repeat Analysis and Tetracycline Resistance

被引：97

作者：

Bakker, D. ^{[1
]}

Corver, J. ^{[1
]}

Harmanus, C. ^{[1
]}

Goorhuis, A. ^{[1
]}

Keessen, E. C. ^{[2
]}

Fawley, W. N. ^{[3
,4
]}

Wilcox, M. H. ^{[3
,4
]}

Kuijper, E. J. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Med Microbiol, Ctr Infect Dis, NL-2300 RC Leiden, Netherlands

[2] Univ Utrecht, Vet Publ Hlth Div, Inst Risk Assessment Sci, Utrecht, Netherlands

[3] Univ Leeds, Leeds, W Yorkshire, England

[4] Leeds Teaching Hosp, Dept Microbiol, Leeds, W Yorkshire, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 10期

关键词：

STAPHYLOCOCCUS-AUREUS; PIGS; TRANSPOSONS; PREVALENCE; INFECTION;

D O I：

10.1128/JCM.01171-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Totals of 102 and 56 Clostridium difficile type 078 strains of human and porcine origins, respectively, from four European countries were investigated by an optimized multilocus variable-number tandem-repeat analysis (MLVA) and for tetracycline susceptibility. Eighty-five percent of all isolates were genetically related, irrespective of human or porcine origin. Human strains were significantly more resistant to tetracycline than porcine strains. All tetracycline-resistant strains contained the Tn916-like transposon harboring the tet(M) gene. We conclude that strains from human and porcine origins are genetically related, irrespective of the country of origin. This may reflect a lack of diversity and/or common source.

引用

页码：3744 / 3749

页数：6

共 25 条

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