Lamellipodia in invasion

被引：112

作者：

Condeelis, JS

Wyckoff, JB

Bailly, M

Pestell, R

Lawrence, D

Backer, J

Segall, JE

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Intravital Imaging Program, Analyt Imaging Facil, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Albert Einstein Canc Comprehens Ctr, Bronx, NY 10461 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

lamellipod; Arp2/3; PI; 3-kinase; cofilin; EGF receptor;

D O I：

10.1006/scbi.2000.0363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In vivo imaging of GFP-labeled metastatic tumor cells reveals cell orientation towards blood vessels. Orientation of tumor cells during chemotactic responses to ligands such as EGF begins with lamellipod extension. Evaluation of some of the downstream events in lamellipod extension indicates: (1) plasma membrane distribution other EGF receptor is uniform bur internalized receptor accumulates on the side of the cell closest to the source of EGF; (2) the alpha p110 isoform of PI-3 kinase is required; ann (3) protrusion of the lamellipod relies upon the combined actions of the Arp2/3 complex and cofilin for generation of filamentous actin.

引用

收藏

页码：119 / 128

页数：10

相关论文

共 55 条

[1] REACTIVATION OF PHOSPHORYLATED ACTIN DEPOLYMERIZING FACTOR AND IDENTIFICATION OF THE REGULATORY SITE [J].

AGNEW, BJ ;

MINAMIDE, LS ;

BAMBURG, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) :17582-17587

[2] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis [J].

Al-Mehdi, AB ;

Tozawa, K ;

Fisher, AB ;

Shientag, L ;

Lee, A ;

Muschel, RJ .

NATURE MEDICINE, 2000, 6 (01) :100-102

[3] Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase [J].

Arber, S ;

Barbayannis, FA ;

Hanser, H ;

Schneider, C ;

Stanyon, CA ;

Bernard, O ;

Caroni, P .

NATURE, 1998, 393 (6687) :805-809

[4] Epidermal growth factor receptor distribution during chemotactic responses [J].

Bailly, M ;

Wyckoff, J ;

Bouzahzah, B ;

Hammerman, R ;

Sylvestre, V ;

Cammer, M ;

Pestell, R ;

Segall, JE .

MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (11) :3873-3883

[5] Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells [J].

Bailly, M ;

Yan, L ;

Whitesides, GM ;

Condeelis, JS ;

Segall, JE .

EXPERIMENTAL CELL RESEARCH, 1998, 241 (02) :285-299

[6]

Bailly M, 1998, MICROSC RES TECHNIQ, V43, P433, DOI 10.1002/(SICI)1097-0029(19981201)43:5<433::AID-JEMT9>3.0.CO

[7]

2-2

[8] Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation [J].

Bailly, M ;

Macaluso, F ;

Cammer, M ;

Chan, A ;

Segall, JE ;

Condeelis, JS .

JOURNAL OF CELL BIOLOGY, 1999, 145 (02) :331-345

[9] Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility [J].

Carlier, MF ;

Laurent, V ;

Santolini, J ;

Melki, R ;

Didry, D ;

Xia, GX ;

Hong, Y ;

Chua, NH ;

Pantaloni, D .

JOURNAL OF CELL BIOLOGY, 1997, 136 (06) :1307-1322

[10] Molecular biology of breast cancer metastasis - Clinical implications of experimental studies on metastatic inefficiency [J].

Chambers, AF ;

Naumov, GN ;

Vantyghem, SA ;

Tuck, AB .

BREAST CANCER RESEARCH, 2000, 2 (06) :400-407

← 1 2 3 4 5 6 →