Explaining the unexpected: Insights from the PLATelet inhibition and clinical Outcomes (PLATO) trial comparing ticagrelor and clopidogrel

被引:33
作者
Ohman, E. Magnus [1 ]
Roe, Matthew T.
机构
[1] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA
关键词
ACUTE CORONARY SYNDROMES; MYOCARDIAL-INFARCTION; GLYCOPROTEIN IIB/IIIA; ELEVATION; ASPIRIN;
D O I
10.1160/TH11-03-0159
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:763 / 765
页数:3
相关论文
共 14 条
[1]   Geographic variability in outcomes within an international trial of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes - Results from PURSUIT [J].
Akkerhuis, KM ;
Deckers, JW ;
Boersma, E ;
Harrington, RA ;
Stepinska, J ;
Mahaffey, KW ;
Wilcox, RG ;
Lincoff, AM ;
Keltai, M ;
Topol, EJ ;
Califf, RM ;
Simoons, ML .
EUROPEAN HEART JOURNAL, 2000, 21 (05) :371-381
[2]   Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial [J].
Bhatt, Deepak L. ;
Flather, Marcus D. ;
Hacke, Werner ;
Berger, Peter B. ;
Black, Henry R. ;
Boden, William E. ;
Cacoub, Patrice ;
Cohen, Eric A. ;
Creager, Mark A. ;
Easton, J. Donald ;
Hamm, Christian W. ;
Hankey, Graeme J. ;
Johnston, S. Claiborne ;
Mak, Koon-Hou ;
Mas, Jean-Louis ;
Montalescot, Gilles ;
Pearson, Thomas A. ;
Steg, P. Gabriel ;
Steinhubl, Steven R. ;
Weber, Michael A. ;
Fabry-Ribaudo, Liz ;
Hu, Tingfei ;
Topol, Eric J. ;
Fox, A. A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (19) :1982-1988
[3]   Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events [J].
Bhatt, DL ;
Fox, KAA ;
Hacke, W ;
Berger, PB ;
Black, HR ;
Boden, WE ;
Cacoub, P ;
Cohen, EA ;
Creager, MA ;
Easton, JD ;
Flather, MD ;
Haffner, SM ;
Hamm, CW ;
Hankey, GJ ;
Johnston, SC ;
Mak, KH ;
Mas, JL ;
Montalescot, G ;
Pearson, TA ;
Steg, PG ;
Steinhubl, SR ;
Weber, MA ;
Brennan, DM ;
Fabry-Ribaudo, L ;
Booth, J ;
Topol, EJ ;
Frye, RL ;
Amarenco, P ;
Brass, LM ;
Buyse, M ;
Cohen, LS ;
DeMets, DL ;
Fuster, V ;
Hart, RG ;
Marler, JR ;
McCarthy, C ;
Schoemig, A ;
Lincoff, AM ;
Brener, SJ ;
Sila, CA ;
Albuquerque, A ;
Aroutiounov, G ;
Artemiev, D ;
Atkeson, BG ;
Bartel, T ;
Basart, DCG ;
Lima, AB ;
Belli, G ;
Bordalo e Sa, AL ;
Bosch, X .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (16) :1706-1717
[4]  
*ISIS 2, 2000, CURR CONTR TRIALS C, V1, P25
[5]   Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial [J].
Mehran, Roxana ;
Pocock, Stuart J. ;
Stone, Gregg W. ;
Clayton, Tim C. ;
Dangas, George D. ;
Feit, Frederick ;
Manoukian, Steven V. ;
Nikolsky, Eugenia ;
Lansky, Alexandra J. ;
Kirtane, Ajay ;
White, Harvey D. ;
Colombo, Antonio ;
Ware, James H. ;
Moses, Jeffrey W. ;
Ohman, E. Magnus .
EUROPEAN HEART JOURNAL, 2009, 30 (12) :1457-1466
[6]  
Ruff CT., 2010, Int J Cardiol
[7]   Viewpoint: Paradoxical excess mortality in the PLATO trial should be independently verified [J].
Serebruany, Victor L. .
THROMBOSIS AND HAEMOSTASIS, 2011, 105 (05) :752-759
[8]   Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention - A randomized controlled trial [J].
Steinhubl, SR ;
Berger, PB ;
Mann, JT ;
Fry, ETA ;
DeLago, A ;
Wilmer, C ;
Topol, EJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (19) :2411-2420
[9]   Bivalirudin for patients with acute coronary syndromes [J].
Stone, Gregg W. ;
McLaurin, Brent T. ;
Cox, David A. ;
Bertrand, Michel E. ;
Lincoff, A. Michael ;
Moses, Jeffrey W. ;
White, Harvey D. ;
Pocock, Stuart J. ;
Ware, James H. ;
Feit, Frederick ;
Colombo, Antonio ;
Aylward, Philip E. ;
Cequier, Angel R. ;
Darius, Harald ;
Desmet, Walter ;
Ebrahimi, Ramin ;
Hamon, Martial ;
Rasmussen, Lars H. ;
Rupprecht, Hans-Juergen ;
Hoekstra, James ;
Mehran, Roxana ;
Ohman, E. Magnus .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (21) :2203-2216
[10]   Ticagrelor in ACS: redefining a new standard of care? [J].
Stone, Gregg W. .
LANCET, 2010, 375 (9711) :263-265