Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue

被引：11

作者：

Bennett, RG

Mahan, KJ

Gentry-Nielsen, MJ

Tuma, DJ

机构：

[1] Vet Affairs Med Ctr, Med Res Serv 151, Dept Med Res, Omaha, NE 68105 USA

[2] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA

[3] Univ Nebraska, Med Ctr, Dept Pharmacol, Omaha, NE 68198 USA

[4] Creighton Univ, Sch Med, Omaha, NE 68131 USA

来源：

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE | 2005年 / 1041卷

关键词：

relaxin; hepatic stellate cell; hepatic fibrosis; LGR7; LGR8; relaxin-3; InsL3;

D O I：

10.1196/annals.1282.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Relaxin has antifibrotic effects on the hepatic stellate cells (HSCs) responsible for collagen deposition in cirrhosis. The expression of relaxin receptors LGR7 and LGR8 in HSCs and liver disease was examined. Activated and quiescent HSCs expressed LGR7, whereas only activated HSCs expressed LGR8. Relaxin, relaxin-3, or InsL3 treatment increased cAMP, suggesting activation of both receptors. LGR8 and LGR7 were present in cirrhotic rat liver, but were undetectable in normal liver. In conclusion, both LGR7 and LGR8 are expressed in activated HSCs and cirrhotic liver, suggesting that relaxin, InsL3, or relaxin-3 may be useful in the treatment of hepatic fibrosis.

引用

页码：185 / 189

页数：5

共 13 条

[1] The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat [J].