Molecular cytogenetics of t(12;21)(p13;q22)

被引：26

作者：

Bernard, OA

Romana, SP

Poirel, H

Berger, R

机构：

[1] U 301 l'Inst. Natl. S. la Rech. Med., SDI No. 15954 I CNRS, Inst. de Genet. Moléculaire, Paris

[2] Unité 301 INSERM, 75010 Paris

来源：

LEUKEMIA & LYMPHOMA | 1996年 / 23卷 / 5-6期

关键词：

molecular cytogenetics; t(12; 21)(p13; q22);

D O I：

10.3109/10428199609054854

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacids of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.

引用

页码：459 / &

页数：8

共 41 条

[1] ABNORMALITIES OF THE SHORT ARM OF CHROMOSOME-12 IN ACUTE NONLYMPHOCYTIC LEUKEMIA AND DYSMYELOPOIETIC SYNDROME [J].

BERGER, R ;

BERNHEIM, A ;

LECONIAT, M ;

VECCHIONE, D ;

PACOT, A ;

DANIEL, MT ;

FLANDRIN, G .

CANCER GENETICS AND CYTOGENETICS, 1986, 19 (3-4) :281-289

[2]

BUIJS A, 1995, ONCOGENE, V10, P1511

[3] LOSS OF HETEROZYGOSITY IN THE CHROMOSOMAL REGION 12P12-13 IS VERY COMMON IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA AND PERMITS THE PRECISE LOCALIZATION OF A TUMOR-SUPPRESSOR GENE DISTINCT FROM P7(KIP1) [J].

CAVE, H ;

GERARD, B ;

MARTIN, E ;

GUIDAL, C ;

DEVAUX, I ;

WEISSENBACH, J ;

ELION, J ;

VILMER, E ;

GRANDCHAMP, B .

BLOOD, 1995, 86 (10) :3869-3875

[4] CONTINUUM OF OVERLAPPING CLONES SPANNING THE ENTIRE HUMAN CHROMOSOME-21Q [J].

CHUMAKOV, I ;

RIGAULT, P ;

GUILLOU, S ;

OUGEN, P ;

BILLAUT, A ;

GUASCONI, G ;

GERVY, P ;

LEGALL, I ;

SOULARUE, P ;

GRINAS, L ;

BOUGUELERET, L ;

BELLANNECHANTELOT, C ;

LACROIX, B ;

BARILLOT, E ;

GESNOUIN, P ;

POOK, S ;

VAYSSEIX, G ;

FRELAT, G ;

SCHMITZ, A ;

SAMBUCY, JL ;

BOSCH, A ;

ESTIVILL, X ;

WEISSENBACH, J ;

VIGNAL, A ;

RIETHMAN, H ;

COX, D ;

PATTERSON, D ;

GARDINER, K ;

HATTORI, M ;

SAKAKI, Y ;

ICHIKAWA, H ;

OHKI, M ;

LEPASLIER, D ;

HEILIG, R ;

ANTONARAKIS, S ;

COHEN, D .

NATURE, 1992, 359 (6394) :380-387

[5]

GHYSDAEL J, 1995, PATHOL BIOL, V43, P202

[6]

GOLUB T, 1995, BLOOD, pA364

[7] FUSION OF PDGF RECEPTOR-BETA TO A NOVEL ETS-LIKE GENE, TEL, IN CHRONIC MYELOMONOCYTIC LEUKEMIA WITH T(512) CHROMOSOMAL TRANSLOCATION [J].

GOLUB, TR ;

BARKER, GF ;

LOVETT, M ;

GILLILAND, DG .

CELL, 1994, 77 (02) :307-316

[8] FUSION OF THE TEL GENE ON 12P13 TO THE AML1 GENE ON 21Q22 IN ACUTE LYMPHOBLASTIC-LEUKEMIA [J].

GOLUB, TR ;

BARKER, GF ;

BOHLANDER, SK ;

HIEBERT, SW ;

WARD, DC ;

BRAYWARD, P ;

MORGAN, E ;

RAIMONDI, SC ;

ROWLEY, JD ;

GILLILAND, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4917-4921

[9]

HARJA A, 1995, MOL CELL BIOL, V15, P4980

[10]

Hiebert SW, 1996, MOL CELL BIOL, V16, P1349

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