Regulation of CD95/Fas signaling at the DISC

被引：300

作者：

Lavrik, I. N. ^{[1
]}

Krammer, P. H. ^{[1
]}

机构：

[1] German Canc Res Ctr, Tumorimmunol Program, Div Immunogenet, D-69120 Heidelberg, Germany

来源：

CELL DEATH AND DIFFERENTIATION | 2012年 / 19卷 / 01期

关键词：

CD95; caspase-8; apoptosis; C-FLIP; DISC; NF-KAPPA-B; FLICE-INHIBITORY PROTEINS; CELL-DEATH; PROCASPASE-8; ACTIVATION; CASPASE-8; INDUCED APOPTOSIS; CD95-INDUCED APOPTOSIS; MEDIATED APOPTOSIS; RECEPTOR SIGNALS; LONG FORM;

D O I：

10.1038/cdd.2011.155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation of the CD95 death-inducing signaling complex (DISC) is the initial step of CD95 signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. The activation of procaspase-8 is blocked by cellular FLICE-inhibitory proteins (c-FLIP). This review is focused on the role in the CD95-mediated signaling of the death effector domain-containing proteins procaspase-8 and c-FLIP. We discuss how dynamic cross-talk between procaspase-8 and c-FLIP at the DISC regulates life/death decisions at CD95. Cell Death and Differentiation (2012) 19, 36-41; doi:10.1038/cdd.2011.155; published online 11 November 2011

引用

页码：36 / 41

页数：6

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