Cellular and network mechanisms of spike-wave seizures

被引:299
作者
Blumenfeld, H
机构
[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA
[3] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA
关键词
seizures; spike-wave rhythms; idiopathic generalized epilepsy;
D O I
10.1111/j.1528-1167.2005.00311.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Spike-wave seizures are often considered a relatively "pure" form of epilepsy, with a uniform defect present in all patients and involvement of the whole brain homogenously. Here, we present evidence against these common misconceptions. Rather than a uniform disorder, spike-wave rhythms arise from the normal inherent network properties of brain excitatory and inhibitory circuits, where they can be provoked by many different insults in several different brain networks. Here we discuss several different cellular and molecular mechanisms that may contribute to the generation of spike-wave seizures, particularly in idiopathic generalized epilepsy. In addition, we discuss growing evidence that electrical, neuroimaging, and molecular changes in spike-wave seizures do not involve the entire brain homogenously. Rather, spike-wave discharges occur selectively in some thalamocortical networks, while sparing others. It is hoped that improved understanding of the heterogeneous defects and selective brain regions involved will ultimately lead to more effective treatments for spike-wave seizures.
引用
收藏
页码:21 / 33
页数:13
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