4-Hydroxy-2-nonenal: a critical target in oxidative stress?

被引：204

作者：

Breitzig, Mason ^{[1
]}

Bhimineni, Charishma ^{[1
]}

Lockey, Richard ^{[1
]}

Kolliputi, Narasaiah ^{[1
]}

机构：

[1] Univ S Florida, Dept Internal Med, Morsani Coll Med, Div Allergy & Immunol, 12901 Bruce B Downs Blvd, Tampa, FL 33612 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2016年 / 311卷 / 04期

基金：

美国国家卫生研究院;

关键词：

4-HNE; ROS; oxidative stress; ALDH2; mitochondria; 4-HYDROXYNONENAL PROTEIN ADDUCTS; LIPID-PEROXIDATION; REACTIVE OXYGEN; IDENTIFICATION; MECHANISMS; DISEASE; INJURY; ALDA-1; ANTIOXIDANTS; PATHOGENESIS;

D O I：

10.1152/ajpcell.00101.2016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In this perspective, we summarize and discuss critical advancements in the study of 4-hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive aldehyde, and a product of lipid peroxidation, studies corroborate its ability to disrupt signal transduction and protein activity, as well as induce inflammation and trigger cellular apoptosis in conditions of oxidative stress. Notably, we discuss the role of natural enzymes involved in the regulation of 4-HNE, and how they can be applied to its detoxification in various physiological conditions.

引用

收藏

页码：C537 / C543

页数：7

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