Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration

被引：20

作者：

Denicourt, C ^{[1
]}

Edouard, E ^{[1
]}

Rassart, E ^{[1
]}

机构：

[1] Univ Quebec, Dept Sci Biol, Mol Biol Lab, Montreal, PQ H3C 3P8, Canada

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 05期

关键词：

D O I：

10.1128/JVI.73.5.4439-4442.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Graffi murine leukemia virus (MuLV) is a nondefective retrovirus that induces granulocytic leukemia in BALB/c and NFS mice. To identify genes involved in Graffi MuLV-induced granulocytic leukemia, tumor cell DNAs were examined for genetic alterations at loci described as common proviral integration sites in MuLV-induced myeloid, lymphoid, and erythroid leukemias. Southern blot analysis revealed rearrangements in c-myc, Fli-1, Pim-1, and Spi-1/PU.1 genes in 20, 10, 3.3, and 3.3% of the tumors tested, respectively. These results demonstrate for the first time the involvement of those genes in granulocytic leukemia.

引用

页码：4439 / 4442

页数：4

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