Chromatin and DNA repair: the benefits of relaxation

被引：29

作者：

Downey, M ^{[1
]}

Durocher, D ^{[1
]}

机构：

[1] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON, Canada

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 01期

关键词：

D O I：

10.1038/ncb0106-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA is tightly wrapped around histones to form chromatin. How DNA repair molecules interact with this chromatin structure is an emerging question. New findings suggest that chromatin structure impedes the access of DNA repair proteins to sites of DNA damage, thus establishing a mechanism for the function of chromatin remodelling complexes during DNA repair.

引用

页码：9 / 10

页数：2

共 14 条

[1] Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair
Bird, AW
Yu, DY
Pray-Grant, MG
Qiu, QF
Harmon, KE
Megee, PC
Grant, PA
Smith, MM
Christman, MF
[J]. NATURE, 2002, 419 (6905) : 411 - 415
[2] Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair
Chai, B
Huang, J
Cairns, BR
Laurent, BC
[J]. GENES & DEVELOPMENT, 2005, 19 (14) : 1656 - 1661
[3] Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
Downs, JA
Allard, S
Jobin-Robitaille, O
Javaheri, A
Auger, A
Bouchard, N
Kron, SJ
Jackson, SP
Côté, J
[J]. MOLECULAR CELL, 2004, 16 (06) : 979 - 990
[4] Dynamics of chromatin during the repair of DNA double-strand breaks
Downs, JA
Côté, J
[J]. CELL CYCLE, 2005, 4 (10) : 1373 - 1376
[5] Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
Ikura, T
Ogryzko, VV
Grigoriev, M
Groisman, R
Wang, J
Horikoshi, M
Scully, R
Qin, J
Nakatani, Y
[J]. CELL, 2000, 102 (04) : 463 - 473
[6] KEOGH MC, 2005, NATURE
[7] Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions
Kusch, T
Florens, L
MacDonald, WH
Swanson, SK
Glaser, RL
Yates, JR
Abmayr, SM
Washburn, MP
Workman, JL
[J]. SCIENCE, 2004, 306 (5704) : 2084 - 2087
[8] INO80 and γ-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair
Morrison, AJ
Highland, J
Krogan, NJ
Arbel-Eden, A
Greenblatt, JF
Haber, JE
Shen, XT
[J]. CELL, 2004, 119 (06) : 767 - 775
[9] Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
Murr, R
Loizou, JI
Yang, YG
Cuenin, C
Li, H
Wang, ZQ
Herceg, Z
[J]. NATURE CELL BIOLOGY, 2006, 8 (01) : 91 - U36
[10] Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
Pierce, AJ
Hu, P
Han, MG
Ellis, N
Jasin, M
[J]. GENES & DEVELOPMENT, 2001, 15 (24) : 3237 - 3242

← 1 2 →