Electroencephalography/functional MRI in human epilepsy: what it currently can and cannot do

被引:76
作者
Laufs, Helmut
Duncan, John S.
机构
[1] Natl Soc Epilepsy, Gerrards Cross SL9 O4J, Bucks, England
[2] UCL, Neurol Inst, Dept Clin & Expt Epilepsy, London, England
基金
英国惠康基金;
关键词
electroencephalography; epilepsy; epilepsy surgery; functional magnetic resonance imaging; interictal epileptic activity;
D O I
10.1097/WCO.0b013e3282202b92
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose of review Simultaneous recording of electroencephalogram and functional MRI is being increasingly applied to the investigation of normal cerebral processes and disorders, particularly epilepsies. We will summarize recent epilepsy-related studies and appraise the clinical and scientific value of EEG/fMRI. Recent findings Interictal and ictal EEG/fMRl can provide helpful information in the presurgical evaluation of epilepsy. At present, EEG/ fMRI cannot supercede any of the current methods because validation studies are lacking, informative results are only obtained in some patients, and haemodynamic activation and deactivation patterns are not always of localizing value. EEG/fMR1 data often identify distributed brain areas and can help to generate concepts of epileptogenic networks both in individual patients and groups with particular epilepsy syndromes. Summary Clinically EEG/fMR1 studies may influence further investigations such as more detailed structural imaging or the planning of intracranial electrophysiological studies by generating hypotheses about the location of epileptic foci. Validation studies are underway to determine whether such clinical applications are appropriate. EEG/fMRl can also assess epileptogenic networks and changes in brain state, leading to a new dimension of understanding of dynamic cerebral processes in health and disease.
引用
收藏
页码:417 / 423
页数:7
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