A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs

被引：24

作者：

Muñoz, P ^{[1
]}

Blanca, J ^{[1
]}

Ramos, A ^{[1
]}

Bartolomé, M ^{[1
]}

García, E ^{[1
]}

Méndez, N ^{[1
]}

Gomez, J ^{[1
]}

de Pozuelo, MM ^{[1
]}

机构：

[1] Agcy Espanola Seguridad Alimentaria, Ctr Nacl Alimentac, Unidad Residuos Zoosanitarios, Madrid 28220, Spain

来源：

ANALYTICA CHIMICA ACTA | 2005年 / 529卷 / 1-2期

关键词：

LC-MS-MS; beta-agonists; corticosteroids; penicillins; chloramphenicol;

D O I：

10.1016/j.aca.2004.06.035

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This work describes an analytical strategy, based on liquid chromatography-tandem mass spectrometry (LC-MS-MS), with a generic chromatographic system in which it is possible to analyse corticosteroids (CORT), beta-agonists (BAG), chloramphenicol (CAP) and penicillins (PEN). The same mobile phase solvents and column were used, and only gradient tables and mass spectrometry acquisition methods were changed depending on the family of compounds to analyse. Different batches of final extracts, proceeding from different analytical methods, may be included in a single sequence and run overnight. Sequence programming and LC-MS-MS conditions are included and typical chromatograms are presented. The proposed approach makes the performance of the analysis of veterinary drug residues more simple, cost-effective and less time-consurning. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：137 / 144

页数：8

共 13 条

[1] Multi-residue extraction-purification procedure for corticosteroids in biological samples for efficient control of their misuse in livestock production
Antignac, JP
Le Bizec, B
Monteau, F
Poulain, F
Andre, F
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2001, 757 (01): : 11 - 19
[2] Antignac JP, 2000, RAPID COMMUN MASS SP, V14, P33, DOI 10.1002/(SICI)1097-0231(20000115)14:1<33::AID-RCM829>3.3.CO
[3] 2-I
[4] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CLENBUTEROL AND CIMATEROL USING POSTCOLUMN DERIVATIZATION
COURTHEYN, D
DESAEVER, C
VERHE, R
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 564 (02): : 537 - 549
[5] DETERMINATION OF DEXAMETHASONE IN URINE AND FECES OF TREATED CATTLE WITH NEGATIVE CHEMICAL-IONIZATION - MASS-SPECTROMETRY
COURTHEYN, D
VERCAMMEN, J
DEBRABANDER, H
VANDENREYT, I
BATJOENS, P
VANOOSTHUYZE, K
VANPETEGHEM, C
[J]. ANALYST, 1994, 119 (12) : 2557 - 2564
[6] DAESELEIRE E, 2000, EURORESIDUE 4, V4, P333
[7] Quantitative determination of several synthetic corticosteroids by gas chromatography mass spectrometry after purification by immunoaffinity chromatography
Delahaut, P
Jacquemin, P
Colemonts, Y
Dubois, M
DeGraeve, J
Deluyker, H
[J]. JOURNAL OF CHROMATOGRAPHY B, 1997, 696 (02): : 203 - 215
[8] MULTI-RESIDUE ANALYSIS FOR BETA-AGONISTIC DRUGS IN URINE OF MEAT-PRODUCING ANIMALS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
MONTRADE, MP
LEBIZEC, B
MONTEAU, F
SILIART, B
ANDRE, F
[J]. ANALYTICA CHIMICA ACTA, 1993, 275 (1-2) : 253 - 268
[9] Analysis of antibiotics by liquid chromatography mass spectrometry
Niessen, WMA
[J]. JOURNAL OF CHROMATOGRAPHY A, 1998, 812 (1-2) : 53 - 75
[10] Determination of chloramphenicol residues in shrimps by liquid chromatography-mass spectrometry
Ramos, M
Muñoz, P
Aranda, A
Rodriguez, I
Diaz, R
Blanca, J
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 791 (1-2): : 31 - 38

← 1 2 →