Acetal-Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non-Phagocytic Cells

被引：90

作者：

Cohen, Joel A. ^{[1
]}

Beaudette, Tristan T. ^{[1
]}

Cohen, Jessica L. ^{[1
]}

Brooders, Kyle E. ^{[1
]}

Bachelder, Eric M. ^{[1
]}

Frechet, Jean M. J. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Coll Chem, Berkeley, CA 94720 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 32期

基金：

美国国家卫生研究院;

关键词：

PLASMID DNA; MICROSPHERES; NANOPARTICLES; POLYMERS; FORMULATION; CARRIERS; RELEASE; ENHANCE; DESIGN;

D O I：

10.1002/adma.201000307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and non-phagocytic cells with minimal toxicity.

引用

页码：3593 / +

页数：6

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