Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons

被引：296

作者：

Bomze, HM

Bulsara, KR

Iskandar, BJ

Caroni, P

Skene, JHP

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Div Neurosurg, Durham, NC 27710 USA

[3] Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA

[4] Friedrich Miescher Inst, CH-4058 Basel, Switzerland

来源：

NATURE NEUROSCIENCE | 2001年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/82881

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In contrast to peripheral nerves, damaged axons in the mammalian brain and spinal cord rarely regenerate. Peripheral nerve injury stimulates neuronal expression of many genes that are not generally induced by CNS lesions, but it is not known which of these genes are required for regeneration. Here we show that co-expressing two major growth cone proteins, GAP-43 and GAP-23, can elicit long axon extension by adult dorsal root ganglion (DRG) neurons in vitro. Moreover, this expression triggers a 60-fold increase in regeneration of DRG axons in adult mice after spinal cord injury in vivo. Replacing key growth cone components, therefore, could be an effective way to stimulate regeneration of CNS axons.

引用

页码：38 / 43

页数：6