Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

被引：4

作者：

Andreassen, Mikkel ^{[1
]}

Frystyk, Jan ^{[2
,3
]}

Miller, Karen K. ^{[4
]}

Kristensen, Lars O. ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev Hosp, Endocrine Unit, Dept Internal Med O,Lab Endocrinol, DK-2730 Herlev, Denmark

[2] Aarhus Univ Hosp, Med Res Labs, Inst Clin, DK-8000 Aarhus C, Denmark

[3] Aarhus Univ Hosp, Med Dept M, DK-8000 Aarhus C, Denmark

[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Neuroendocrine Unit,Dept Med, Boston, MA 02115 USA

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2010年 / 70卷 / 07期

关键词：

Multiple sclerosis; interferon-beta treatment; growth hormone; insulin-like growth factor-I; insulin-like growth factor I receptor; GROWTH-FACTOR-I; DISEASE; SERUM;

D O I：

10.3109/00365513.2010.521256

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We describe a 34-year-old female treated with IFN-beta for 8 years with a biochemical profile suggestive of acromegaly. The patient presented with elevated serum insulin-like growth factor-I (IGF-I) and insufficient suppression of growth hormone (GH) during oral glucose tolerance test (OGTT). There were no clinical features of acromegaly. A 5-day profile showed higher GH levels on the 3 days following IFN-beta injections. Total and bioactive IGF-I were also elevated but did not fluctuate. Four weeks off IFN-beta normalized suppression of GH during OGTT but did not reduce serum IGF-I or bioactive IGF-I. In conclusion, IFN-beta treatment mimicked acromegaly biochemically. The changes were partially reversible.

引用

页码：519 / 522

页数：4

共 15 条

[1] Long-term follow-up of 106 multiple sclerosis patients undergoing interferon-β 1a or 1b therapy:: Predictive factors of thyroid disease development and duration [J].