Unrelated cord blood transplantation in children with sickle cell disease: Review of four-center experience

被引：59

作者：

Adamkiewicz, Tom V.

Szabolcs, Paul

Haight, Ann

Baker, K. Scott

Staba, Susan

Kedar, Amos

Chiang, K. Y.

Krishnamurti, Lakshmanan

Boyer, Michael W.

Kurtzberg, Joan

Wagner, John E.

Wingard, John R.

Yeager, Andrew M.

机构：

[1] Morehouse Sch Med, Div Res, Dept Family Med, E Point, GA 30344 USA

[2] Duke Univ, Durham, NC USA

[3] Emory Univ, Atlanta, GA 30322 USA

[4] Univ Minnesota, Minneapolis, MN USA

[5] Univ Florida, Gainesville, FL USA

[6] Univ Pittsburgh, Pittsburgh, PA USA

[7] Univ Utah, Hlth Sci Ctr, Salt Lake City, UT USA

[8] Univ Arizona, Tucson, AZ USA

来源：

PEDIATRIC TRANSPLANTATION | 2007年 / 11卷 / 06期

关键词：

sickle cell disease; umbilical cord transplant; unrelated donor transplant; reduced intensity conditioning;

D O I：

10.1111/j.1399-3046.2007.00725.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.

引用

页码：641 / 644

页数：4

共 24 条

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