Ebola hemorrhagic fever: Evaluation of passive immunotherapy in nonhuman primates

被引：92

作者：

Jahrling, Peter B.

Geisbert, Joan B.

Swearengen, James R.

Larsen, Thomas

Geisbert, Thomas W.

机构：

[1] NIH, NIAID, Integrated Res Facil, Bethesda, MD 20892 USA

[2] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA

[3] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA

[4] Associat Assessment & Accreditat Lab Anim Care I, Rockville, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷

关键词：

D O I：

10.1086/520587

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The survival of 7 of 8 patients with Ebola virus (EBOV) infection after transfusions of convalescent-phase blood during a 1995 outbreak of EBOV infection is frequently cited as evidence that passive immunotherapy is a viable treatment option. To test whether whole-blood transfusions were more efficacious than passively administered immunoglobulins or monoclonal antibodies, we transfused convalescent-phase blood from EBOV-immune monkeys into naive animals shortly after challenge with EBOV. Although passively acquired antibody titers comparable to those associated with effective vaccination were obtained, all monkeys that had received transfusions succumbed to infection concurrently with control monkeys. These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection.

引用

页码：S400 / S403

页数：4

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