Effect of the antimalarial drug Halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A

被引：20

作者：

Piippo, K

Holmström, S

Swan, H

Viitasalo, M

Raatikka, M

Toivonen, L

Kontula, K

机构：

[1] Univ Helsinki Hosp, Dept Med, Helsinki, Finland

[2] Univ Helsinki Hosp, Hosp Children & Adolescents, Helsinki, Finland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 07期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/S0002-9149(00)01538-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the first LQTS-causing mutation thus far localized in the S5 segment of the fourth SCN5A cardiac sodium channel domain. In 2 of mutation carriers, antimalarial therapy with halofantrine induced a marked prolongation of the QTc interval and torsades de pointes, demonstrating that specific drag treatment may induce ventricular tachycardia in LQT3.

引用

页码：909 / +

页数：4

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