Dynamic personalities of proteins

被引：1882

作者：

Henzler-Wildman, Katherine ^{[1
]}

Kern, Dorothee ^{[1
]}

机构：

[1] Brandeis Univ, Howard Hughes Med Inst, Dept Biochem, Waltham, MA 02454 USA

来源：

NATURE | 2007年 / 450卷 / 7172期

关键词：

D O I：

10.1038/nature06522

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Because proteins are central to cellular function, researchers have sought to uncover the secrets of how these complex macromolecules execute such a fascinating variety of functions. Although static structures are known for many proteins, the functions of proteins are governed ultimately by their dynamic character ( or 'personality'). The dream is to 'watch' proteins in action in real time at atomic resolution. This requires addition of a fourth dimension, time, to structural biology so that the positions in space and time of all atoms in a protein can be described in detail.

引用

页码：964 / 972

页数：9

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