Allyl isothiocyanate regulates caspase-1/receptor interacting protein-2 expression

被引：12

作者：

Han, Na-Ra ^{[1
]}

Park, Wansu ^{[2
]}

Um, Jae-Young ^{[1
]}

Kim, Hyung-Min ^{[1
]}

Jeong, Hyun-Ja ^{[3
]}

机构：

[1] Kyung Hee Univ, Coll Oriental Med, Dept Pharmacol, Seoul 130701, South Korea

[2] Kyungwon Univ, Coll Oriental Med, Songnam 461701, South Korea

[3] Hoseo Univ, Biochip Res Ctr, Asan 336795, Chungnam, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 04期

关键词：

Allyl isothiocyanate; Human mast cells; Calcium; Caspase-1; Receptor interacting proteins-2; Interleukin-1; beta; KAPPA-B ACTIVATION; MAST-CELLS; RELEASE; INTERLEUKIN-1-BETA; RIP2; LIPOPOLYSACCHARIDE; MACROPHAGES; SUPPRESSION; INHIBITION; APOPTOSIS;

D O I：

10.1016/j.intimp.2010.12.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Isothiocyanates can inhibit nuclear factor-kappaB (NF-kappaB) activation. Interleukin (IL)-1 beta activates the NF-kappaB, which in turn activates proteins involved in inflammation. IL-1 beta is directly associated with caspase-1 activation. We tested the anti-inflammatory effect of allyl isothiocyanate (AITC) in mast cells. AITC suppressed the intracellular calcium level in the phorbol myristate acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line. AITC decreased PMA plus A23187-induced cystein-aspartic acid protease (caspase)-1 activity. Particularly, AITC decreased PMA plus A23187-induced caspase-1/receptor interacting protein-2 expression as well as the mRNA expression and production of IL-1 beta. An in-depth research of the cellular targets of the AITC is warranted. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：525 / 528

页数：4

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