Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices

被引:24
作者
Cox, BA
Johnson, SW
机构
[1] Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA
[2] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA
关键词
N-methyl-D-aspartate; nitric oxide; brain slice; burst firing; L-arginine; N-nitro-L-arginine methyl ester; dopamine neuron; substantia nigra; ventral tegmental area;
D O I
10.1016/S0304-3940(98)00737-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 mu M) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 mu M), a substrate for nitric oxide (NO) production, increased both the number of spikes per burst and the magnitude of interburst hyperpolarizations. Nitric oxide synthase inhibitors N-nitro-L-arginine methyl ester (L-NAME, 100 mu M), N-nitro-L-arginine, and 7-nitroindazole inhibited NMDA-induced burst firing by reducing the number of spikes per burst. Moreover, L-arginine (100 mu M) reversed the inhibition of burst firing produced by L-NAME. These findings suggest that NO facilitates NMDA-induced burst firing in DA neurons. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:131 / 134
页数:4
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