Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France

被引：32

作者：

Weber, P

Filipecki, J

Bingen, E

Fitoussi, F

Goldfarb, G

Chauvin, JP

Reitz, C

Portier, H

机构：

[1] BIO VSM, Med Biol Lab, F-77360 Vaires Sur Marne, France

[2] Lab Abbott, Rungis, France

[3] Ctr Hosp Univ Robert Debre, Microbiol Serv, Paris, France

[4] Ctr Hosp Univ Bocage, Serv Malad Infect, Dijon, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 48卷 / 02期

关键词：

D O I：

10.1093/jac/48.2.291

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Three hundred and three strains of group A streptococci (GAS) isolated from adults with pharyngitis were tested to evaluate their phenotype of resistance to macrolides-lincosamides and to search for macrolide resistance genes. MICs of clarithromycin were determined. The overall rate of resistance to both erythromycin and clarithromycin was 9.6%. Constitutive, inducible and M phenotypes of resistance were detected in 4.3, 2 and 3.3% of strains, respectively. All constitutive phenotypes harboured ermB genes, whereas inducible phenotypes had the ermTR gene and M phenotypes had the mefA gene. In France, the current resistance rate of GAS to erythromycin and clarithromycin remains low.

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页码：291 / 294

页数：4

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