Kidney Pathology Precedes and Predicts the Pathological Cascade of Cerebrovascular Lesions in Stroke Prone Rats

被引：23

作者：

Schreiber, Stefanie ^{[1
]}

Bueche, Celine Z. ^{[1
]}

Garz, Cornelia ^{[1
]}

Kropf, Siegfried ^{[2
]}

Kuester, Doerthe ^{[3
]}

Amann, Kerstin ^{[4
]}

Heinze, Hans-Jochen ^{[1
,5
,6
]}

Goertler, Michael ^{[1
]}

Reymann, Klaus G. ^{[5
,6
]}

Braun, Holger ^{[5
]}

机构：

[1] Otto Von Guericke Univ, Dept Neurol, Magdeburg, Germany

[2] Otto Von Guericke Univ, Inst Biometry & Med Informat, Magdeburg, Germany

[3] Otto Von Guericke Univ, Inst Pathol, Magdeburg, Germany

[4] Univ Erlangen Nurnberg, Dept Nephropathol, Erlangen, Germany

[5] Deutsch Zentrum Neurodegenerat Erkrankungen, Magdeburg, Germany

[6] Leibniz Inst Neurobiol, Magdeburg, Germany

来源：

PLOS ONE | 2011年 / 6卷 / 10期

关键词：

SMALL-VESSEL DISEASE; SPONTANEOUSLY HYPERTENSIVE RAT; BRAIN; PROTEINURIA; EXPRESSION; FAILURE; INJURY; ATTACK; RENIN;

D O I：

10.1371/journal.pone.0026287

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Introduction: Human cerebral small vessel disease (CSVD) has been hypothesized to be an age-dependent disease accompanied by similar vascular changes in other organs. SHRSP feature numerous vascular risk factors and may be a valid model of some aspects of human CSVD. Here we compare renal histopathological changes with the brain pathology of spontaneously hypertensive stroke-prone rats (SHRSP). Material and Methods: We histologically investigated the brains and kidneys of 61 SHRSP at different stages of age (12 to 44 weeks). The brain pathology (aggregated erythrocytes in capillaries and arterioles, microbleeds, microthromboses) and the kidney pathology (aggregated erythrocytes within peritubular capillaries, tubular protein cylinders, glomerulosclerosis) were quantified separately. The prediction of the brain pathology by the kidney pathology was assessed by creating ROC-curves integrating the degree of kidney pathology and age of SHRSP. Results: Both, brain and kidney pathology, show an age-dependency and proceed in definite stages whereas an aggregation of erythrocytes in capillaries and arterioles, we parsimoniously interpreted as stases, represent the initial finding in both organs. Thus, early renal tubulointerstitial damage characterized by rather few intravasal erythrocyte aggregations and tubular protein cylinders predicts the initial step of SHRSPs' cerebral vascular pathology marked by accumulated erythrocytes. The combined increase of intravasal erythrocyte aggregations and protein cylinders accompanied by glomerulosclerosis and thrombotic renal microangiopathy in kidneys of older SHRSP predicts the final stages of SHRSPs' cerebrovascular lesions marked by microbleeds and thrombotic infarcts. Conclusion: Our results illustrate a close association between structural brain and kidney pathology and support the concept of small vessel disease to be an age-dependent systemic pathology. Further, an improved joined nephrologic and neurologic diagnostic may help to identify patients with CSVD at an early stage.

引用

页数：10

共 26 条

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