New insight on the photoreactivity of the phototoxic anti-cancer flutamide: photochemical pathways selectively locked and unlocked by structural changes upon drug compartmentalization in phospholipid bilayer vesicles

被引：38

作者：

Sortino, S

Marconi, G

Condorelli, G

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[2] Ist Fotochim & Radiaz Alta Energia, Area Ric, I-40129 Bologna, Italy

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 13期

关键词：

D O I：

10.1039/b102359b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is shown that structural changes of the phototoxic anti-cancer drug flutamide after its compartmentalization in unilamellar phospholipid bilayer vesicles lead to a highly selective modification of the photochemical outcome, locking the main photodegradation pathways observed in homogeneous media and unlocking a new and more efficient photoreactive channel.

引用

页码：1226 / 1227

页数：2

共 13 条

[1]

Adel MS, 1997, PHARMAZIE, V52, P373

[2] ORGANIC PHOTOCHEMISTRY .8. PHOTOCHEMICAL REDUCTION OF NITRO-COMPOUNDS [J].