The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model

被引：76

作者：

Bigi, Adriana ^{[2
]}

Fini, Milena ^{[1
]}

Bracci, Barbara ^{[2
]}

Boanini, Elisa ^{[2
]}

Torricelli, Paola ^{[1
]}

GiavareSi, Gianluca ^{[1
]}

Aldini, Nicolo N. ^{[1
]}

Facchini, Alessandro ^{[3
]}

Sbaiz, Fausto ^{[3
]}

Giardino, Roberto ^{[1
]}

机构：

[1] Rizzoli Orthopaed Inst, Res Inst Cadivilla Putti, Expt Surg Lab, I-40136 Bologna, Italy

[2] Univ Bologna, Dept Chem G Ciamician, I-40126 Bologna, Italy

[3] Lima Lto Spa, I-33030 Udine, Italy

来源：

BIOMATERIALS | 2008年 / 29卷 / 11期

关键词：

titanium alloys; niobium; biomimetic material; hydroxyapatite; osteointegration;

D O I：

10.1016/j.biomaterials.2007.12.011

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An in vivo study was carried out on uncoated and hydroxyapatite (HA)-coated nanostructured Ti13Nb11Zr alloy in comparison with high-grade Ti6A14V, to investigate the effect of the different surfaces on osteointegration rate. A highly effective method to obtain a fast biomimetic deposition of a thin layer of nanocrystalline HA was applied to coat both substrates. Cylindrical pins were implanted in rabbit conical bone and evaluated at 4 and 12 weeks by histomorphometry and microhardness tests. The results confirmed the ability of the slightly supersaturated Ca/P solution to induce a fast deposition of nanocrystalline HA on Ti alloys' surfaces. HA-coated Ti13Nb11Zr had the highest osteointegration rate at 4 and 12 weeks. Both HA-coated surfaces showed an affinity index significantly higher than those of native surfaces at 4 weeks (Ti13Nb11Zr + HA: 37%; Ti6A14V + HA: 26%). Microhardness test showed a significantly higher bone mineralization index of HA-coated Ti13Nb1Zr in comparison with that of HA-coated Ti6A14V surface. The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti-Nb-Zr alloy with the HA coating on bone remodeling and maturation. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1730 / 1736

页数：7

共 30 条

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