Guam dementia syndrome revisited in 2011

被引：16

作者：

Lee, Suzee E. ^{[1
]}

机构：

[1] Univ Calif San Francisco, UCSF Dept Neurol, Memory Aging Ctr, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN NEUROLOGY | 2011年 / 24卷 / 06期

关键词：

amyotrophic lateral sclerosis; Guam dementia; lytico-bodig; Mariana's dementia; parkinsonism dementia complex of Guam; AMYOTROPHIC-LATERAL-SCLEROSIS; ALPHA-SYNUCLEIN PATHOLOGY; MOTOR-NEURON DISEASE; PARKINSONISM-DEMENTIA; NEUROFIBRILLARY TANGLES; KII-PENINSULA; NEURODEGENERATIVE DISORDERS; CLINICAL-FEATURES; ENDEMIC DISEASE; LYTICO-BODIG;

D O I：

10.1097/WCO.0b013e32834cd50a

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Purpose of review This review covers the amyotrophic lateral sclerosis (ALS)/parkinsonism dementia complex (PDC) of Guam. Clinical and epidemiological characteristics, genetic possible and environmental causes, and neuropathological features of the disease are discussed. Recent findings Recent studies of clinical syndromes and neuropathological studies are compared with previous descriptions of the disease. The latest genetic and environmental studies are also reviewed. Summary In recent years, understanding of the molecular pathogenesis of neurodegenerative diseases has evolved. ALS/PDC shares neuropathological features found in many neurodegenerative diseases such as Alzheimer's disease, Lewy body disease, and frontotemporal lobar degeneration. Thus, examining ALS/PDC may provide further explanations on how various proteins seen in neurodegenerative disorders may be interrelated.

引用

页码：517 / 524

页数：8

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