Vitamin D metabolism within bone cells: Effects on bone structure and strength

被引：47

作者：

Anderson, Paul H. ^{[1
,2
,4
]}

Atkins, Gerald J. ^{[3
,4
]}

Turner, Andrew G. ^{[2
,4
]}

Kogawa, Masakazu ^{[3
]}

Findlay, David M. ^{[3
,4
]}

Morris, Howard A. ^{[1
,2
,4
]}

机构：

[1] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5000, Australia

[2] SA Pathol, Endocrine Bone Res Lab, Chem Pathol, Adelaide, SA 5000, Australia

[3] Univ Adelaide, Bone Cell Biol Grp, Discipline Orthopaed & Trauma, Adelaide, SA 5000, Australia

[4] Hanson Inst, Adelaide, SA 5000, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 347卷 / 1-2期

关键词：

Vitamin D metabolism; Osteoblast; Bone architecture; Osteoclast; Bone cell metabolism; MESSENGER-RNA EXPRESSION; MINERAL ION HOMEOSTASIS; 25-HYDROXYVITAMIN-D; 1-ALPHA-HYDROXYLASE; 5'-FLANKING REGION; D SUPPLEMENTATION; GENE-EXPRESSION; D INSUFFICIENCY; HIP FRACTURE; FEMORAL-NECK; D DEFICIENCY;

D O I：

10.1016/j.mce.2011.05.024

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D-3) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D-3) to 1,25(OH)(2)D-3, which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D-3 in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：42 / 47

页数：6

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