Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

被引：113

作者：

Jansen, Peter L. M. ^{[1
]}

van Werven, Jochem ^{[2
]}

Aarts, Edo ^{[3
]}

Berends, Frits ^{[3
]}

Janssen, Ignace ^{[3
]}

Stoker, Jaap ^{[2
]}

Schaap, Frank G. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Gastrointestinal & Liver Dis, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands

[3] Rijnstate Hosp, Dept Surg, Arnhem, Netherlands

来源：

DIGESTIVE DISEASES | 2011年 / 29卷 / 01期

关键词：

Fibroblast growth factor 19; Fibroblast growth factor 21; Bile salts; Bariatric surgery; METABOLISM; OBESITY;

D O I：

10.1159/000324128

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：48 / 51

页数：4

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