The development of inducible bronchus-associated lymphoid tissue depends on IL-17

被引：364

作者：

Rangel-Moreno, Javier ^{[1
]}

Carragher, Damian M. ^{[2
]}

Garcia-Hernandez, Maria de la Luz ^{[1
]}

Hwang, Ji Young ^{[1
]}

Kusser, Kim ^{[1
]}

Hartson, Louise ^{[1
]}

Kolls, Jay K. ^{[3
]}

Khader, Shabaana A. ^{[4
]}

Randall, Troy D. ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Med, Div Allergy Immunol & Rheumatol, Rochester, NY 14642 USA

[2] Trudeau Inst Inc, Saranac Lake, NY 12983 USA

[3] Louisiana State Univ, Dept Genet, Hlth Sci Ctr, New Orleans, LA USA

[4] Univ Pittsburgh, Sch Med, Dept Pediat, Div Infect Dis, Pittsburgh, PA 15261 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 07期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; CD45(+)CD4(+)CD3(-) CELLS; RETINOIC ACID; TH17; CELLS; LYMPHOTOXIN; EXPRESSION; SECONDARY; CHEMOKINES; ALPHA; DIFFERENTIATION;

D O I：

10.1038/ni.2053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Ectopic or tertiary lymphoid tissues, such as inducible bronchus-associated lymphoid tissue (iBALT), form in nonlymphoid organs after local infection or inflammation. However, the initial events that promote this process remain unknown. Here we show that iBALT formed in mouse lungs as a consequence of pulmonary inflammation during the neonatal period. Although we found CD4(+)CD3(-) lymphoid tissue-inducer cells (LTi cells) in neonatal lungs, particularly after inflammation, iBALT was formed in mice that lacked LTi cells. Instead, we found that interleukin 17 (IL-17) produced by CD4(+) T cells was essential for the formation of iBALT. IL-17 acted by promoting lymphotoxin-a-independent expression of the chemokine CXCL13, which was important for follicle formation. Our results suggest that IL-17-producing T cells are critical for the development of ectopic lymphoid tissues.

引用

页码：639 / U195

页数：9

共 55 条

[1]

Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease [J].