Blood and urinary levels of ethanol, acetaldehyde, and C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male students after ethanol ingestion

被引：44

作者：

Otsuka, M ^{[1
]}

Harada, N ^{[1
]}

Itabashi, T ^{[1
]}

Ohmori, S ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 700, Japan

来源：

ALCOHOL | 1999年 / 17卷 / 02期

关键词：

diacetyl; acetoin; 2,3-butanediol; genotype; ALDH2;

D O I：

10.1016/S0741-8329(98)00042-1

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Aldehyde dehydrogenase (ALDH) isozyme 2 genes were determined in 15 students. Of these subjects, five healthy male students were administered 0.4 kg/kg ethanol. One subject was defective in aldehyde dehydrogenase 2 (ALDH2), two had normal ALDH2, and the other two were hetero type. After the intake of alcohol, the concentration of ethanol, acetaldehyde, and C-4 compounds in blood and urine were determined. The student with the inactive form of ALDH2 was flushed and his levels of 2,3-butanediol and acetaldehyde in blood and urine were found to be the highest. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：119 / 124

页数：6

共 24 条

[1] DISPOSITION OF ETHANOL IN HUMAN MATERNAL VENOUS-BLOOD AND AMNIOTIC-FLUID [J].