RNA sequence- and shape-dependent recognition by proteins in the ribonucleoprotein particle

被引:126
作者
Stefl, R [1 ]
Skrisovska, L [1 ]
Allain, FHT [1 ]
机构
[1] ETH Honggerberg, Swiss Fed Inst Technol Zurich, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland
关键词
double-stranded RNA-binding motif; RNA-binding proteins; RNA recognition; RNA-recognition motif; zinc-finger motif;
D O I
10.1038/sj.embor.7400325
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
At all stages of its life ( from transcription to translation), an RNA transcript interacts with many different RNA-binding proteins. The composition of this supramolecular assembly, known as a ribonucleoprotein particle, is diverse and highly dynamic. RNA-binding proteins control the generation, maturation and lifespan of the RNA transcript and thus regulate and influence the cellular function of the encoded gene. Here, we review our current understanding of protein-RNA recognition mediated by the two most abundant RNA-binding domains (the RNA-recognition motif and the double-stranded RNA-binding motif) plus the zinc-finger motif, the most abundant nucleic-acid-binding domain. In addition, we discuss how not only the sequence but also the shape of the RNA are recognized by these three classes of RNA-binding protein.
引用
收藏
页码:33 / 38
页数:6
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