Hypoxia, gene expression, and metastasis

被引：319

作者：

Chan, Denise A. ^{[1
]}

Giaccia, Amato J. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiat Oncol, Div Canc & Radiat Biol, Stanford, CA 94305 USA

来源：

CANCER AND METASTASIS REVIEWS | 2007年 / 26卷 / 02期

关键词：

hypoxia; hypoxia-inducible factor; metastasis; angiogenesis; radiotherapy; chemotherapy;

D O I：

10.1007/s10555-007-9063-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

引用

页码：333 / 339

页数：7

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