Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital

被引:22
作者
Chai, Yi Ann Louis
Wang, Yue
Khoo, Ai Leng
Chan, Fong Yee
Chow, Carol
Kumarasinghe, Gamini
Singh, Kamaljit
Tambyah, Paul Ananth
机构
[1] Natl Univ Singapore Hosp, Dept Med, Singapore 117548, Singapore
[2] Inst Mol & Cell Biol, Microbial Collect & Screening Lab, Singapore, Singapore
[3] Natl Univ Singapore Hosp, Dept Pharm, Singapore 117548, Singapore
[4] Natl Univ Singapore Hosp, Dept Lab Med, Singapore 117548, Singapore
[5] Rush Univ, Med Ctr, Chicago, IL 60612 USA
[6] Natl Univ Singapore, Fac Med, Singapore 117548, Singapore
关键词
Candida tropicalis; Singapore; epidemiology;
D O I
10.1080/13693780701385868
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
An 18- month epidemiologic investigation of Candida bloodstream infections in a Singapore hospital identified 52 candidemic patients: 36% of whose infections were caused by C. tropicalis, 29% were due to C. albicans, 10% with C. parapsilosis and 21% involved C. glabrata. A predominant clonal C. tropicalis strain was demonstrated. No association with ICU stay, prior exposure to fluconazole/ broad- spectrum antibiotics or increased mortality was found in this apparent shift towards non- albicans Candida species as the primary agents of candidemia.
引用
收藏
页码:435 / 439
页数:5
相关论文
共 20 条
[1]   The epidemiology of hematogenous candidiasis caused by different Candida species [J].
AbiSaid, D ;
Anaissie, E ;
Uzun, O ;
Raad, I ;
Pinzcowski, H ;
Vartivarian, S .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (06) :1122-1128
[2]  
Al-Jasser AM, 2004, SAUDI MED J, V25, P566
[3]   Trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital [J].
Berrouane, YF ;
Herwaldt, LA ;
Pfaller, MA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :531-537
[4]   Risk factors for candidal bloodstream infections in surgical intensive care unit patients: The NEMIS Prospective Multicenter Study [J].
Blumberg, HM ;
Jarvis, WR ;
Soucie, JM ;
Edwards, JE ;
Patterson, JE ;
Pfaller, MA ;
Rangel-Frausto, MS ;
Rinaldi, MG ;
Saiman, L ;
Wiblin, RT ;
Wenzel, RP .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (02) :177-186
[5]   Stable susceptibility of Candida blood isolates to fluconazole despite increasing use during the past 10 years [J].
Chen, YC ;
Chang, SC ;
Luh, KT ;
Hsieh, WC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (01) :71-77
[6]  
Foongladda Suporn, 2004, Journal of the Medical Association of Thailand, V87, P92
[7]   Fluconazole and the changing epidemiology of candidemia [J].
Girmenia, C ;
Martino, P .
CLINICAL INFECTIOUS DISEASES, 1998, 27 (01) :232-233
[8]   Epidemiology of candidemia in Swiss tertiary care hospitals:: Secular trends, 1991-2000 [J].
Marchetti, O ;
Bille, J ;
Fluckiger, U ;
Eggimann, P ;
Ruef, C ;
Garbino, J ;
Calandra, T ;
Glauser, MP ;
Täuber, MG ;
Pittet, D .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (03) :311-320
[9]   Correlation between E-test, disk diffusion, and microdilution methods for antifungal susceptibility testing of fluconazole and voriconazole [J].
Matar, MJ ;
Ostrosky-Zeichner, L ;
Paetznick, VL ;
Rodriguez, JR ;
Chen, E ;
Rex, JH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) :1647-1651
[10]  
Mathews MS, 2001, MYCOSES, V44, P278, DOI 10.1111/j.1439-0507.2001.00641.x